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1

CCR3 Antagonists: A Potential New Therapy for the Treatment of Asthma. Discovery and Structure—Activity Relationships.

Dean A. Wacker, John V. Duncia, et al. et al.

Journal:

Year:

2002

File:

PDF, 30 KB

2002

2

Discovery of N-Propylurea 3-Benzylpiperidines as Selective CC Chemokine Receptor-3 (CCR3) Antagonists.

Dean A. Wacker, et al. et al.

Journal:

Year:

2004

File:

PDF, 70 KB

2004

3

CC chemokine receptor-3 (CCR3) antagonists: Improving the selectivity of DPC168 by reducing central ring lipophilicity

James R. Pruitt, Douglas G. Batt, Dean A. Wacker, Lori L. Bostrom, Shon K. Booker, Erin McLaughlin, Gregory C. Houghton, Jeffrey G. Varnes, David D. Christ, Maryanne Covington, Anuk M. Das, Paul Davie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

4

N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists

Douglas G. Batt, Gregory C. Houghton, John Roderick, Joseph B. Santella III, Dean A. Wacker, Patricia K. Welch, Yevgeniya I. Orlovsky, Eric A. Wadman, James M. Trzaskos, Paul Davies, Carl P. Decicco,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 278 KB

english, 2005

5

Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Jeffrey G. Varnes, Dean A. Wacker, Irina C. Jacobson, Mimi L. Quan, Christopher D. Ellis, Karen A. Rossi, Ming Y. He, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y.S. Lam, Ruth R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 188 KB

english, 2007

6

Structure–activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors

Jeffrey G. Varnes, Dean A. Wacker, Donald J.P. Pinto, Michael J. Orwat, Jay P. Theroff, Brian Wells, Robert A. Galemo, Joseph M. Luettgen, Robert M. Knabb, Steven Bai, Kan He, Patrick Y.S. Lam, Ruth R

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 164 KB

english, 2008

7

From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis

Joseph B. Santella III, Daniel S. Gardner, Wenqing Yao, Chongsheng Shi, Prabhakar Reddy, Andrew J. Tebben, George V. DeLucca, Dean A. Wacker, Paul S. Watson, Patricia K. Welch, Eric A. Wadman, Paul Da

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 373 KB

english, 2008

8

Site-specific incorporation of non-natural residues into peptides: Effect of residue structure on suppression and translation efficiencies

J.D. Bain, Dean A. Wacker, Eric E. Kuo, A.Richard Chamberlin

Journal:

Year:

1991

Language:

english

File:

PDF, 1.16 MB

english, 1991

9

Efficient solid-phase synthesis of 2,3-substituted indoles

Dean A Wacker, Padmaja Kasireddy

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

10

Facile preparation of chloromethylaryl solid supports using methanesulfonyl chloride and Hunig's base

David A Nugiel, Dean A Wacker, Gregory A Nemeth

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 123 KB

english, 1997

11

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure–activity relationships

Dean A Wacker, Joseph B Santella, III, Daniel S Gardner, Jeffrey G Varnes, Melissa Estrella, George V DeLucca, Soo S Ko, Keiichi Tanabe, Paul S Watson, Patricia K Welch, Maryanne Covington, Nicole C S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 136 KB

english, 2002

12

Irreversible Inhibition of High-Affinity [3H]Kainate Binding by a Novel Photoactivatable Analogue: (2′S,3′S,4′R)-2′-Carboxy-4′-(2-Diazo-1-Oxo-3,3,3-Trifluoropropyl)-3′-Pyrrolidinyl Acetate

Colin L. Willis, Dean A. Wacker, Richard D. Bartlett, David Bleakman, David Lodge, A. Richard Chamberlin, Richard J. Bridges

Journal:

Journal of Neurochemistry

Year:

1997

Language:

english

File:

PDF, 851 KB

english, 1997

13

Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semi-synthetic aminoacyl-tRNAs

Dix, Thomas A., Chamberlin, A. Richard, Bain, J. D., Diala, Edward S., Glabe, Charles G., Wacker, Dean A., Lyttle, Matthew H.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.45 MB

english, 1991

14

Discovery of CC Chemokine Receptor-3 (CCR3) Antagonists with Picomolar Potency

De Lucca, George V., Kim, Ui Tae, Vargo, Brian J., Duncia, John V., Santella, Joseph B., Gardner, Daniel S., Zheng, Changsheng, Liauw, Ann, Wang, Zhang, Emmett, George, Wacker, Dean A., Welch, Patrici

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 360 KB

english, 2005

15

Discovery of ( R )-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1- a ]isoindol- 6(2 H )-one, a Selective, Orally Active Agonist of the 5-HT 2C Receptor

Wacker, Dean A., Varnes, Jeffrey G., Malmstrom, Sarah E., Cao, Xueying, Hung, Chen-Pin, Ung, Thao, Wu, Ginger, Zhang, Ge, Zuvich, Eva, Thomas, Michael A., Keim, William J., Cullen, Mary Jane, Rohrbach

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 191 KB

english, 2007

16

Discovery and development of 5-HT 2C receptor agonists for obesity: is there light at the end of the tunnel?

Miller, Keith J, Wacker, Dean A

Journal:

Future Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.37 MB

english, 2010

17

Solid-Phase Synthesis of Alkyl Aryl Ethers via the Ullmann Condensation

Xiao,, Li, Rongshi, Hurst, David, Zhuang, Hui, Shi, Shuhao, Czarnik, Anthony W., Robichaud, Albert J., Wacker, Dean A., Robertson, David W.

Journal:

Journal of Combinatorial Chemistry

Year:

2002

Language:

english

File:

PDF, 101 KB

english, 2002

18

Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1 H )-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119

Wacker, Dean A., Wang, Ying, Broekema, Matthias, Rossi, Karen, O’Connor, Steven, Hong, Zhenqiu, Wu, Ginger, Malmstrom, Sarah E., Hung, Chen-Pin, LaMarre, Linda, Chimalakonda, Anjaneya, Zhang, Lisa, Xi

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

19

Preparation of chemically misacylated semisynthetic nonsense suppressor tRNAs employed in biosynthetic incorporation of non-natural residues into proteins

Bain, J. D., Wacker, Dean A., Kuo, Eric E., Lyttle, Matthew H., Chamberlin, A. Richard

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 2.32 MB

english, 1991

20

A Selective Photoaffinity Ligand for the Kainate Class of Excitatory Amino Acid Receptor

Wacker, Dean, Lovering, Frank, Bridges, Richard, Willis, Colin, Bartlett, Richard, Chamberlin, A.

Journal:

Year:

1997

File:

PDF, 254 KB

1997

21

Efficient Preparation of (3 S )-3-(4-Fluorobenzyl)piperidinium Mandelate

Emmett, George C., Cain, Gary A., Estrella, Melissa J., Holler, Edd R., Piecara, James S., Blum, Andrew M., Mical, Alfred J., Teleha, Christopher A., Wacker, Dean A.

Journal:

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

22

Life times of metastable states guide regulatory signaling in transcriptional riboswitches

Helmling, Christina, Klötzner, Dean-Paulos, Sochor, Florian, Mooney, Rachel Anne, Wacker, Anna, Landick, Robert, Fürtig, Boris, Heckel, Alexander, Schwalbe, Harald

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.56 MB

english, 2018

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